| Date | Location | Result | |
| Nov 01, 2005 | Morrow, GA | Clayton State 2, USC Upstate 0 | Box score |
| Oct 29, 2005 | Morrow, GA | Clayton State 1, USC Upstate 0 | Box score |
| Oct 25, 2005 | Clinton, SC | Presbyterian 2, USC Upstate 0 | Box score |
| Oct 22, 2005 | Spartanburg, SC | USC Upstate 2, USC Aiken 1 | Box score |
| Oct 18, 2005 | Spartanburg, SC | Armstrong Atl. St. 3, USC Upstate 0 | Box score |
| Oct 14, 2005 | Spartanburg, SC | Columbus State 4, USC Upstate 0 | Box score |
| Oct 12, 2005 | Greenwood, SC | Lander 4, USC Upstate 0 | Box score |
| Oct 08, 2005 | Pembroke, NC | UNC Pembroke 3, USC Upstate 0 | Box score |
| Oct 04, 2005 | Spartanburg, SC | Tusculum 1, USC Upstate 0 | Box score |
| Sep 30, 2005 | Milledgeville, GA | Ga. Col. & St. Univ. 2, USC Upstate 1 | Box score |
| Sep 27, 2005 | Mars Hill, NC | USC Upstate 3, Mars Hill 2 | Box score |
| Sep 21, 2005 | Spartanburg, SC | Carson-Newman 3, USC Upstate 1 | Box score |
| Sep 14, 2005 | Belmont, NC | Belmont Abbey 1, USC Upstate 0 | Box score |
| Sep 10, 2005 | Spartanburg, SC | USC Upstate 4, North Georgia 0 | Box score |
| sep 04, 2005 | Greeneville, TN | Barry 0, USC Upstate 0 | Box score |
| Sep 02, 2005 | Greeneville, TN | USC Upstate 2, Angelo St. 1 | Box score |
| Aug 31, 2005 | Spartanburg, SC | Lenoir-Rhyne 1, USC Upstate 1 | Box score |
| Aug 28, 2005 | Golden, CO | Colorado Mines 3, USC Upstate 2 | Box score |
| Aug 26, 2005 | Denver, CO | Metro State 7, USC Upstate 0 | Box score |